Six jurisdictions that participated in SET-NET reported data on women with syphilis during pregnancy and outcomes that occurred during 2018–2021. Frequencies of adverse outcomes were reported by syphilis treatment status during pregnancy as defined by the 2021 Sexually Transmitted Infections Treatment Guidelines (inadequate, adequate, and no treatment).

Last year, congenital syphilis led to six stillbirths in North Carolina and two neonatal deaths, according to preliminary data....